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Miniaturisation of barcoding

Miniaturisation of barcoding technology brings us one step closer to home diagnostics

Rising rates of later age illness including cancer, cardiovascular diseases, Alzheimer's, Parkinson's and diabetes have burdened society in the past decades and has rasied critical demands for more efficient, affordable healthcare. Novel medical diagnostic technologies seek to identify disease biomarkers at the earliest possible stage, potentially intercepting more serious illness through disease prevention rather than therapy. Advances in nanotechnology are providing new medical applications and raising expectations for improved diagnostic technologies and paving the way towards personalised medicine.

In the ever expanding area of bioaccurate and more reliable sensor systems, there has been an expanding interest in the exploitation of nanomaterials and, in particular, the employment of nanostructured interfaces as a transduction element. Our approach employs magnetic elements in combination to optically active surfaces for rapid in-flow diagnostics.sensor development towards faster, cheaper, more 

"Bioassays are labor intensive, expensive and take specialized training with expensive equipment".Micron-scale Barcodes can be written & rewritten with an external field
"Bioassays are labor intensive, expensive and take specialized training with expensive equipment". Micron-scale Barcodes can be written & rewritten with an external field


 

Features of our in-house micro-magnetic barcoding technology include:

  • Nominally identical, micron-sized tags
  • Globally addressable magnetic bits
  • In-flow magnetic read-out
  • >100,000 unique code

 

Point of care Diagnostics - Over 100,000 disease markers tested in minutes, at home!

Current diagnosis strategies with disease biomarkers are largely based on the light emitted by pretreated labeled probe molecules which interact with specific substrate-bound receptors. This is expensive, time-consuming and has limited sensitivity. Fortunately, groundbreaking developments in understanding biological interfaces at nanostructured surfaces opens up possibilities for a range of promising sensor applications.

 

 

Micromagnetic barcode DNA bioassay: magnetic barcodes are encased in a polymer shell and covered with biomarkers for in-flow optical detection.Nanostructured surfaces on the magnetic barcode carrier offer the possibility to reach high sensitivity in every assay
Micromagnetic barcode DNA bioassay: magnetic barcodes are encased in a polymer shell and covered with biomarkers for in-flow optical detection. Micron-scale Barcodes can be written & rewritten with an external field

 

 

 

 

 

 

 

Christian Cimorra