skip to primary navigationskip to content
 

Shake it up every once in a while…

Using tiny vibrating magnets to destroy cancer cells

I am developing a targeted therapy for brain cancer, and while biochemists have used various cocktails of drugs to destroy cancerous cells, the cells have proved frustratingly resilient to date. The present treatment for brain cancer often involves a combination of surgery, radiotherapy, and chemotherapy, and yet sadly the mortality rate with this cancer remains high. The most common brain cancer, glioblastoma multiforme, is notoriously aggressive. And it’s also really, really hard to reach the brain with drugs, since it’s separated from circulating blood by the blood-brain barrier, making treatment incredibly challenging.  

As a physicist, I’m in over my head in the fields of biochemistry and drug development, so I invoke a different approach to attacking these cancerous cells. Interestingly, cells are responsive to mechanical stimuli, and poking, prodding, and vibrating a cell can lead to quite profound effects on cell functions. Dial up the mechanical stimulation enough, and you can even cause a shutdown of cellular function and destruction of the cell. We can potentially use this to destroy tumour cells, but how to exert forces on cells in a place you can’t necessarily reach, and how do you do it at a time of your choosing?

Magnetic Disks
Tiny magnetic discs that can be vibrated to destroy cancerous cells

Since iron filings feel the effect of a magnet from quite a distance, and move in response to the motion of the magnet, magnetism is a pretty effective way of exerting force at a distance. I build magnetic particles that respond in a specific manner to magnetic fields, but they are discs that are one micron in diameter, and only a few hundred nanometres thick. A single one of these magnetic discs looks rather like a pancake, except shrunk down a hundred thousand times! This means that I can inject them into a tumour and make them either infiltrate or attach to the cancerous cells. If I then apply a rotating magnetic field to the tumour area, the injected particles rotate and oscillate in response to the field. This mechanical stimulus is enough to seriously damage and even kill cells, often by destroying the integrity of the cell membrane.

With this work, I’m using an unconventional approach to damage and destroy cancerous tissue, and initial in-vitro results have been quite positive, where 90% of the cancer cells were killed after just a few minutes of applying the rotating magnetic field. I’m looking forward to the further testing of this therapy in-vivo, and to tackling the new challenges that this will bring!

Tarun Vemulkar

NanoDTC PhD Student Cohort 2012

 

Image Source for top banner: NIMH

RSS Feed Latest news

Midi+PhD Project Proposals from Cambridge Academics

Dec 19, 2018

We are now accepting project proposals for Midi (May-Jul 2019) + PhD projects (starting Oct 2019) for our c2018 students. Deadline 18 Feb.

NanoDTC student paper published in Nature Comms

Dec 07, 2018

c2013 student Jasmine Rivett was the first author on the recent paper, “Long-lived polarization memory in the electronic states of lead-halide perovskites from local structural dynamics” in Nature Communications.

Applications for Oct 2019 entry

Nov 15, 2018

We are now accepting applications for entry in Oct 2019. The deadline to be considered for the 1st round of shortlisting is 5th Dec 2018.

Black researchers shaping the future

Oct 13, 2018

As the UK marks Black History Month, researchers from across the University talk about their route to Cambridge, their inspiration and their motivation.