Our students have been involved in new and exciting interdisciplinary research and have published in leading high impact journals including Nature Chemistry, Nature Communications, JACS, Angewandte Chemie, Applied Physics Letters, ACS Nano, Nano Letters, Advanced Materials, Nature Protocols, PloS one, and many others.
A full list of the work published by our NanoDTC Students, Associates and others, acknowledging the NanoDTC grants EP/G037221, EP/L015978 and EP/S022953/1 is below. If you want to view the papers on google scholar, see here.
Some papers published by our students are also featured below with some additional contextual information.
Last updated: Mar 2021
Looking inside lithium-ion batteries
Spectroscopy and Electrocatalysis for a Sustainable Future
From waste to fuel: quantifying sustainability
Novel spin states discovered in silicon-based artificial atoms
A step forward in efficient artificial photosynthesis
Self-assembling hydrogels on microfluidic droplets that respond to light or chemical stimuli by disassembling
2013
32.
Salvatore, Stefano; Demetriadou, Angela; Vignolini, Silvia; Oh, Sang Soon; Wuestner, Sebastian; Yufa, Nataliya A; Stefik, Morgan; Wiesner, Ulrich; Baumberg, Jeremy J; Hess, Ortwin; others,
Tunable 3D extended self-assembled gold metamaterials with enhanced light transmission Journal Article
In: Advanced Materials, vol. 25, no. 19, pp. 2713–2716, 2013.
@article{salvatore2013tunable,
title = {Tunable 3D extended self-assembled gold metamaterials with enhanced light transmission},
author = {Stefano Salvatore and Angela Demetriadou and Silvia Vignolini and Sang Soon Oh and Sebastian Wuestner and Nataliya A Yufa and Morgan Stefik and Ulrich Wiesner and Jeremy J Baumberg and Ortwin Hess and others},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201300193},
year = {2013},
date = {2013-01-01},
journal = {Advanced Materials},
volume = {25},
number = {19},
pages = {2713--2716},
publisher = {WILEY-VCH Verlag},
abstract = {The optical properties of metamaterials made by block copolymer self‐assembly are tuned by structural and environmental variations. The plasma frequency red‐shifts with increasing lattice constant and blue‐shifts as the network filling fraction increases. Infiltration with dielectric liquids leads also to a red‐shift of the plasma edge. A 300 nm‐thick slab of gyroid‐structured gold has a remarkable transmission of 20%.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The optical properties of metamaterials made by block copolymer self‐assembly are tuned by structural and environmental variations. The plasma frequency red‐shifts with increasing lattice constant and blue‐shifts as the network filling fraction increases. Infiltration with dielectric liquids leads also to a red‐shift of the plasma edge. A 300 nm‐thick slab of gyroid‐structured gold has a remarkable transmission of 20%.
31.
Howe, Richard CT; Smalley, Adam P; Guttenplan, Alexander PM; Doggett, Matthew WR; Eddleston, Mark D; Tan, Jin Chong; Lloyd, Gareth O
A family of simple benzene 1, 3, 5-tricarboxamide (BTA) aromatic carboxylic acid hydrogels Journal Article
In: Chemical Communications, vol. 49, no. 39, pp. 4268–4270, 2013.
@article{howe2013family,
title = {A family of simple benzene 1, 3, 5-tricarboxamide (BTA) aromatic carboxylic acid hydrogels},
author = {Richard CT Howe and Adam P Smalley and Alexander PM Guttenplan and Matthew WR Doggett and Mark D Eddleston and Jin Chong Tan and Gareth O Lloyd},
url = {https://pubs.rsc.org/ko/content/articlelanding/2013/cc/c2cc37428e/unauth#!divAbstract},
year = {2013},
date = {2013-01-01},
journal = {Chemical Communications},
volume = {49},
number = {39},
pages = {4268--4270},
publisher = {Royal Society of Chemistry},
abstract = {We present the characterisation of a hydrogel forming family of benzene 1,3,5-tricarboxamide (BTA) aromatic carboxylic acid derivatives. The simple, easy to synthesise compounds presented here exhibit consistent gel formation at low concentrations through the use of a pH trigger.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
We present the characterisation of a hydrogel forming family of benzene 1,3,5-tricarboxamide (BTA) aromatic carboxylic acid derivatives. The simple, easy to synthesise compounds presented here exhibit consistent gel formation at low concentrations through the use of a pH trigger.
30.
Forse, Alexander C; Griffin, John M; Wang, Hao; Trease, Nicole M; Presser, Volker; Gogotsi, Yury; Simon, Patrice; Grey, Clare P
Nuclear magnetic resonance study of ion adsorption on microporous carbide-derived carbon Journal Article
In: Physical Chemistry Chemical Physics, vol. 15, no. 20, pp. 7722–7730, 2013.
@article{forse2013nuclear,
title = {Nuclear magnetic resonance study of ion adsorption on microporous carbide-derived carbon},
author = {Alexander C Forse and John M Griffin and Hao Wang and Nicole M Trease and Volker Presser and Yury Gogotsi and Patrice Simon and Clare P Grey},
url = {https://pubs.rsc.org/hy/content/articlehtml/2013/cp/c3cp51210j},
year = {2013},
date = {2013-01-01},
journal = {Physical Chemistry Chemical Physics},
volume = {15},
number = {20},
pages = {7722--7730},
publisher = {Royal Society of Chemistry},
abstract = {A detailed understanding of ion adsorption within porous carbon is key to the design and improvement of electric double-layer capacitors, more commonly known as supercapacitors. In this work nuclear magnetic resonance (NMR) spectroscopy is used to study ion adsorption in porous carbide-derived carbons. These predominantly microporous materials have a tuneable pore size which enables a systematic study of the effect of pore size on ion adsorption. Multinuclear NMR experiments performed on the electrolyte anions and cations reveal two main environments inside the carbon. In-pore ions (observed at low frequencies) are adsorbed inside the pores, whilst ex-pore ions (observed at higher frequencies) are not adsorbed and are in large reservoirs of electrolyte between carbon particles. All our experiments were carried out in the absence of an applied electrical potential in order to assess the mechanisms related to ion adsorption without the contribution of electrosorption. Our results indicate similar adsorption behaviour for anions and cations. Furthermore, we probe the effect of sample orientation, which is shown to have a marked effect on the NMR spectra. Finally, we show that a 13C → 1H cross polarisation experiment enables magnetisation transfer from the carbon architecture to the adsorbed species, allowing selective observation of the adsorbed ions and confirming our spectral assignments.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
A detailed understanding of ion adsorption within porous carbon is key to the design and improvement of electric double-layer capacitors, more commonly known as supercapacitors. In this work nuclear magnetic resonance (NMR) spectroscopy is used to study ion adsorption in porous carbide-derived carbons. These predominantly microporous materials have a tuneable pore size which enables a systematic study of the effect of pore size on ion adsorption. Multinuclear NMR experiments performed on the electrolyte anions and cations reveal two main environments inside the carbon. In-pore ions (observed at low frequencies) are adsorbed inside the pores, whilst ex-pore ions (observed at higher frequencies) are not adsorbed and are in large reservoirs of electrolyte between carbon particles. All our experiments were carried out in the absence of an applied electrical potential in order to assess the mechanisms related to ion adsorption without the contribution of electrosorption. Our results indicate similar adsorption behaviour for anions and cations. Furthermore, we probe the effect of sample orientation, which is shown to have a marked effect on the NMR spectra. Finally, we show that a 13C → 1H cross polarisation experiment enables magnetisation transfer from the carbon architecture to the adsorbed species, allowing selective observation of the adsorbed ions and confirming our spectral assignments.
29.
Strange, Daniel Geoffrey Tyler
Mechanics of biomimetic materials for tissue engineering of the intervertebral disc PhD Thesis
University of Cambridge, 2013.
@phdthesis{strange2013mechanics,
title = {Mechanics of biomimetic materials for tissue engineering of the intervertebral disc},
author = {Daniel Geoffrey Tyler Strange},
url = {https://www.repository.cam.ac.uk/handle/1810/244660},
year = {2013},
date = {2013-01-01},
school = {University of Cambridge},
abstract = {Tissue engineering offers a paradigm shift in the treatment of back pain. Engineered intervertebral discs could replace degenerated tissue and overcome the limitations of current treatments that disrupt the biomechanics of the spine. New materials, which exhibit sophisticated mechanical responses, are needed to provide templates for tissue regeneration. These behaviours include time-dependent deformation---facilitating shock absorption and nutrient transfer---and strong material anisotropy and tensile-compressive nonlinearities---providing flexibility in controlled directions. In this work, frameworks for the design of materials with controllable structure-property relationships are developed. The time-dependent mechanical properties of composites of agar, alginate and gelatin hydrogels are investigated. It is shown that the time-dependent responses of the composites can be tuned over a wide range. It is then demonstrated that materials mimicking the fibre-reinforced nature of natural tissues can be developed by infiltrating thick electrospun fibre networks with alginate. These fibre-reinforced hydrogels have tensile and compressive properties that can be separately altered. To better understand the mechanical behaviour of these hydrogel-based materials, improved methods for characterising poroelastic and poroviscoelastic time-dependent material properties using indentation are developed. It is shown that poroviscoelastic relaxation is the product of separate poroelastic and viscoelastic relaxation responses. The techniques developed here provide a methodology to rapidly characterise the properties of time-dependent materials and to create materials with complex structure-property relationships similar to those found in natural tissues; they present a framework for biomimetic materials design. The work in this thesis can be used to inform the design of clinically relevant tissue engineering treatments and help the quarter of a million people each year who undergo spinal surgery to reduce back pain.},
keywords = {},
pubstate = {published},
tppubtype = {phdthesis}
}
Tissue engineering offers a paradigm shift in the treatment of back pain. Engineered intervertebral discs could replace degenerated tissue and overcome the limitations of current treatments that disrupt the biomechanics of the spine. New materials, which exhibit sophisticated mechanical responses, are needed to provide templates for tissue regeneration. These behaviours include time-dependent deformation---facilitating shock absorption and nutrient transfer---and strong material anisotropy and tensile-compressive nonlinearities---providing flexibility in controlled directions. In this work, frameworks for the design of materials with controllable structure-property relationships are developed. The time-dependent mechanical properties of composites of agar, alginate and gelatin hydrogels are investigated. It is shown that the time-dependent responses of the composites can be tuned over a wide range. It is then demonstrated that materials mimicking the fibre-reinforced nature of natural tissues can be developed by infiltrating thick electrospun fibre networks with alginate. These fibre-reinforced hydrogels have tensile and compressive properties that can be separately altered. To better understand the mechanical behaviour of these hydrogel-based materials, improved methods for characterising poroelastic and poroviscoelastic time-dependent material properties using indentation are developed. It is shown that poroviscoelastic relaxation is the product of separate poroelastic and viscoelastic relaxation responses. The techniques developed here provide a methodology to rapidly characterise the properties of time-dependent materials and to create materials with complex structure-property relationships similar to those found in natural tissues; they present a framework for biomimetic materials design. The work in this thesis can be used to inform the design of clinically relevant tissue engineering treatments and help the quarter of a million people each year who undergo spinal surgery to reduce back pain.
28.
Wang, Hao; Forse, Alexander C; Griffin, John M; Trease, Nicole M; Trognko, Lorie; Taberna, Pierre-Louis; Simon, Patrice; Grey, Clare P
In situ NMR spectroscopy of supercapacitors: insight into the charge storage mechanism Journal Article
In: Journal of the American Chemical Society, vol. 135, no. 50, pp. 18968–18980, 2013.
@article{wang2013situ,
title = {In situ NMR spectroscopy of supercapacitors: insight into the charge storage mechanism},
author = {Hao Wang and Alexander C Forse and John M Griffin and Nicole M Trease and Lorie Trognko and Pierre-Louis Taberna and Patrice Simon and Clare P Grey},
url = {https://pubs.acs.org/doi/abs/10.1021/ja410287s},
year = {2013},
date = {2013-01-01},
journal = {Journal of the American Chemical Society},
volume = {135},
number = {50},
pages = {18968--18980},
publisher = {American Chemical Society},
abstract = {Electrochemical capacitors, commonly known as supercapacitors, are important energy storage devices with high power capabilities and long cycle lives. Here we report the development and application of in situ nuclear magnetic resonance (NMR) methodologies to study changes at the electrode–electrolyte interface in working devices as they charge and discharge. For a supercapacitor comprising activated carbon electrodes and an organic electrolyte, NMR experiments carried out at different charge states allow quantification of the number of charge storing species and show that there are at least two distinct charge storage regimes. At cell voltages below 0.75 V, electrolyte anions are increasingly desorbed from the carbon micropores at the negative electrode, while at the positive electrode there is little change in the number of anions that are adsorbed as the voltage is increased. However, above a cell voltage of 0.75 V, dramatic increases in the amount of adsorbed anions in the positive electrode are observed while anions continue to be desorbed at the negative electrode. NMR experiments with simultaneous cyclic voltammetry show that supercapacitor charging causes marked changes to the local environments of charge storing species, with periodic changes of their chemical shift observed. NMR calculations on a model carbon fragment show that the addition and removal of electrons from a delocalized system should lead to considerable increases in the nucleus-independent chemical shift of nearby species, in agreement with our experimental observations.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Electrochemical capacitors, commonly known as supercapacitors, are important energy storage devices with high power capabilities and long cycle lives. Here we report the development and application of in situ nuclear magnetic resonance (NMR) methodologies to study changes at the electrode–electrolyte interface in working devices as they charge and discharge. For a supercapacitor comprising activated carbon electrodes and an organic electrolyte, NMR experiments carried out at different charge states allow quantification of the number of charge storing species and show that there are at least two distinct charge storage regimes. At cell voltages below 0.75 V, electrolyte anions are increasingly desorbed from the carbon micropores at the negative electrode, while at the positive electrode there is little change in the number of anions that are adsorbed as the voltage is increased. However, above a cell voltage of 0.75 V, dramatic increases in the amount of adsorbed anions in the positive electrode are observed while anions continue to be desorbed at the negative electrode. NMR experiments with simultaneous cyclic voltammetry show that supercapacitor charging causes marked changes to the local environments of charge storing species, with periodic changes of their chemical shift observed. NMR calculations on a model carbon fragment show that the addition and removal of electrons from a delocalized system should lead to considerable increases in the nucleus-independent chemical shift of nearby species, in agreement with our experimental observations.
27.
Patera, Laerte L; Africh, Cristina; Weatherup, Robert S; Blume, Raoul; Bhardwaj, Sunil; Castellarin-Cudia, Carla; Knop-Gericke, Axel; Schloegl, Robert; Comelli, Giovanni; Hofmann, Stephan; others,
In situ observations of the atomistic mechanisms of Ni catalyzed low temperature graphene growth Journal Article
In: ACS nano, vol. 7, no. 9, pp. 7901–7912, 2013.
@article{patera2013situ,
title = {In situ observations of the atomistic mechanisms of Ni catalyzed low temperature graphene growth},
author = {Laerte L Patera and Cristina Africh and Robert S Weatherup and Raoul Blume and Sunil Bhardwaj and Carla Castellarin-Cudia and Axel Knop-Gericke and Robert Schloegl and Giovanni Comelli and Stephan Hofmann and others},
url = {https://pubs.acs.org/doi/abs/10.1021/nn402927q},
year = {2013},
date = {2013-01-01},
journal = {ACS nano},
volume = {7},
number = {9},
pages = {7901--7912},
publisher = {American Chemical Society},
abstract = {The key atomistic mechanisms of graphene formation on Ni for technologically relevant hydrocarbon exposures below 600 °C are directly revealed via complementary in situ scanning tunneling microscopy and X-ray photoelectron spectroscopy. For clean Ni(111) below 500 °C, two different surface carbide (Ni2C) conversion mechanisms are dominant which both yield epitaxial graphene, whereas above 500 °C, graphene predominantly grows directly on Ni(111) via replacement mechanisms leading to embedded epitaxial and/or rotated graphene domains. Upon cooling, additional carbon structures form exclusively underneath rotated graphene domains. The dominant graphene growth mechanism also critically depends on the near-surface carbon concentration and hence is intimately linked to the full history of the catalyst and all possible sources of contamination. The detailed XPS fingerprinting of these processes allows a direct link to high pressure XPS measurements of a wide range of growth conditions, including polycrystalline Ni catalysts and recipes commonly used in industrial reactors for graphene and carbon nanotube CVD. This enables an unambiguous and consistent interpretation of prior literature and an assessment of how the quality/structure of as-grown carbon nanostructures relates to the growth modes.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The key atomistic mechanisms of graphene formation on Ni for technologically relevant hydrocarbon exposures below 600 °C are directly revealed via complementary in situ scanning tunneling microscopy and X-ray photoelectron spectroscopy. For clean Ni(111) below 500 °C, two different surface carbide (Ni2C) conversion mechanisms are dominant which both yield epitaxial graphene, whereas above 500 °C, graphene predominantly grows directly on Ni(111) via replacement mechanisms leading to embedded epitaxial and/or rotated graphene domains. Upon cooling, additional carbon structures form exclusively underneath rotated graphene domains. The dominant graphene growth mechanism also critically depends on the near-surface carbon concentration and hence is intimately linked to the full history of the catalyst and all possible sources of contamination. The detailed XPS fingerprinting of these processes allows a direct link to high pressure XPS measurements of a wide range of growth conditions, including polycrystalline Ni catalysts and recipes commonly used in industrial reactors for graphene and carbon nanotube CVD. This enables an unambiguous and consistent interpretation of prior literature and an assessment of how the quality/structure of as-grown carbon nanostructures relates to the growth modes.
26.
Gershon, Talia S; Sigdel, Ajaya K; Marin, Andrew T; van Hest, Maikel FAM; Ginley, David S; Friend, Richard H; MacManus-Driscoll, Judith L; Berry, Joseph J
Improved fill factors in solution-processed ZnO/Cu2O photovoltaics Journal Article
In: Thin Solid Films, vol. 536, pp. 280–285, 2013.
@article{gershon2013improved,
title = {Improved fill factors in solution-processed ZnO/Cu2O photovoltaics},
author = {Talia S Gershon and Ajaya K Sigdel and Andrew T Marin and Maikel FAM van Hest and David S Ginley and Richard H Friend and Judith L MacManus-Driscoll and Joseph J Berry},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0040609013004872},
year = {2013},
date = {2013-01-01},
journal = {Thin Solid Films},
volume = {536},
pages = {280--285},
publisher = {Elsevier},
abstract = {The influence of semiconductor layer morphology on the performance of solution-processed ZnO/Cu2O photovoltaics has been examined. ZnO films were prepared using three highly scalable, cost-effective methods: electrodeposition, zinc acetate decomposition, and diethyl zinc decomposition. To optimize device performance, it is found that a low density of nano-scale pores in the ZnO layer and large grains in the Cu2O is necessary. Through optimizing the ZnO morphology, one of the highest fill factors observed to date (up to 54%) in solution-processed ZnO/Cu2O was achieved. This value is comparable with the fill factor of the record-efficiency ZnO/Cu2O device, which was prepared with much larger energy inputs.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The influence of semiconductor layer morphology on the performance of solution-processed ZnO/Cu2O photovoltaics has been examined. ZnO films were prepared using three highly scalable, cost-effective methods: electrodeposition, zinc acetate decomposition, and diethyl zinc decomposition. To optimize device performance, it is found that a low density of nano-scale pores in the ZnO layer and large grains in the Cu2O is necessary. Through optimizing the ZnO morphology, one of the highest fill factors observed to date (up to 54%) in solution-processed ZnO/Cu2O was achieved. This value is comparable with the fill factor of the record-efficiency ZnO/Cu2O device, which was prepared with much larger energy inputs.
25.
Salmon, Andrew R; Capener, Matthew J; Baumberg, Jeremy J; Elliott, Stephen R
Rapid microcantilever-thickness determination by optical interferometry Journal Article
In: Measurement Science and Technology, vol. 25, no. 1, pp. 015202, 2013.
@article{salmon2013rapid,
title = {Rapid microcantilever-thickness determination by optical interferometry},
author = {Andrew R Salmon and Matthew J Capener and Jeremy J Baumberg and Stephen R Elliott},
url = {https://iopscience.iop.org/article/10.1088/0957-0233/25/1/015202/meta},
year = {2013},
date = {2013-01-01},
journal = {Measurement Science and Technology},
volume = {25},
number = {1},
pages = {015202},
publisher = {IOP Publishing},
abstract = {Silicon microcantilevers are widely used in scanning-probe microscopy and in cantilever-sensing applications. However, the cantilever thickness is not well controlled in conventional lithography and, since it is also difficult to measure, it is the most important undefined factor in mechanical variability. An accurate method to measure this parameter is thus essential. We demonstrate the capability to measure microcantilever thicknesses rapidly (>1 Hz) and accurately (±2 nm) by optical interferometry. This is achieved with standard microscopy equipment and so can be implemented as a standard technique in both research and in batch control for commercial microfabrication. In addition, we show how spatial variations in the thickness of individual microcantilevers can be mapped, which has applications in the precise mechanical calibration of cantilevers for force spectroscopy.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Silicon microcantilevers are widely used in scanning-probe microscopy and in cantilever-sensing applications. However, the cantilever thickness is not well controlled in conventional lithography and, since it is also difficult to measure, it is the most important undefined factor in mechanical variability. An accurate method to measure this parameter is thus essential. We demonstrate the capability to measure microcantilever thicknesses rapidly (>1 Hz) and accurately (±2 nm) by optical interferometry. This is achieved with standard microscopy equipment and so can be implemented as a standard technique in both research and in batch control for commercial microfabrication. In addition, we show how spatial variations in the thickness of individual microcantilevers can be mapped, which has applications in the precise mechanical calibration of cantilevers for force spectroscopy.
24.
Guldin, Stefan
Inorganic nanoarchitectures by organic self-assembly Miscellaneous
2013.
@misc{guldin2013inorganic,
title = {Inorganic nanoarchitectures by organic self-assembly},
author = {Stefan Guldin},
url = {https://books.google.co.uk/books?hl=en&lr=&id=OfdDAAAAQBAJ&oi=fnd&pg=PR5&dq=info:0Qzh_p2VZaUJ:scholar.google.com&ots=zZB6IKgD1k&sig=kXNmCXCCefAayiztTQRVWLhqFAY&redir_esc=y#v=onepage&q&f=false},
year = {2013},
date = {2013-01-01},
publisher = {Springer Science & Business Media},
abstract = {Macromolecular self-assembly - driven by weak, non-covalent, intermolecular forces - is a common principle of structure formation in natural and synthetic organic materials. The variability in material arrangement on the nanometre length scale makes this an ideal way of matching the structure-function demands of photonic and optoelectronic devices. However, suitable soft matter systems typically lack the appropriate photoactivity, conductivity or chemically stability. This thesis explores the implementation of soft matter design principles for inorganic thin film nanoarchitectures. Sacrificial block copolymers and colloids are employed as structure-directing agents for the co-assembly of solution-based inorganic materials, such as TiO_2 and SiO_2. Novel fabrication and characterization methods allow unprecedented control of material formation on the 10 – 500 nm length scale, allowing the design of material architectures with interesting photonic and optoelectronic properties.},
keywords = {},
pubstate = {published},
tppubtype = {misc}
}
Macromolecular self-assembly - driven by weak, non-covalent, intermolecular forces - is a common principle of structure formation in natural and synthetic organic materials. The variability in material arrangement on the nanometre length scale makes this an ideal way of matching the structure-function demands of photonic and optoelectronic devices. However, suitable soft matter systems typically lack the appropriate photoactivity, conductivity or chemically stability. This thesis explores the implementation of soft matter design principles for inorganic thin film nanoarchitectures. Sacrificial block copolymers and colloids are employed as structure-directing agents for the co-assembly of solution-based inorganic materials, such as TiO_2 and SiO_2. Novel fabrication and characterization methods allow unprecedented control of material formation on the 10 – 500 nm length scale, allowing the design of material architectures with interesting photonic and optoelectronic properties.
23.
Sutherland, William J; Goulden, Chris; Bell, Kate; Bennett, Fran; Burall, Simon; Bush, Marc; Callan, Samantha; Catcheside, Kim; Corner, Julian; Dárcy, Conor T; others,
100 Questions: identifying research priorities for poverty prevention and reduction Journal Article
In: Journal of Poverty and Social Justice, vol. 21, no. 3, pp. 189–205, 2013.
@article{sutherland2013100,
title = {100 Questions: identifying research priorities for poverty prevention and reduction},
author = {William J Sutherland and Chris Goulden and Kate Bell and Fran Bennett and Simon Burall and Marc Bush and Samantha Callan and Kim Catcheside and Julian Corner and Conor T Dárcy and others},
url = {https://www.ingentaconnect.com/content/tpp/jpsj/2013/00000021/00000003/art00001},
year = {2013},
date = {2013-01-01},
journal = {Journal of Poverty and Social Justice},
volume = {21},
number = {3},
pages = {189--205},
publisher = {Policy Press},
abstract = {Reducing poverty is important for those affected, for society and the economy. Poverty remains entrenched in the UK, despite considerable research efforts to understand its causes and possible solutions. The Joseph Rowntree Foundation, with the Centre for Science and Policy at the University of Cambridge, ran a democratic, transparent, consensual exercise involving 45 participants from government, non-governmental organisations, academia and research to identify 100 important research questions that, if answered, would help to reduce or prevent poverty. The list includes questions across a number of important themes, including attitudes, education, family, employment, heath, wellbeing, inclusion, markets, housing, taxes, inequality and power.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Reducing poverty is important for those affected, for society and the economy. Poverty remains entrenched in the UK, despite considerable research efforts to understand its causes and possible solutions. The Joseph Rowntree Foundation, with the Centre for Science and Policy at the University of Cambridge, ran a democratic, transparent, consensual exercise involving 45 participants from government, non-governmental organisations, academia and research to identify 100 important research questions that, if answered, would help to reduce or prevent poverty. The list includes questions across a number of important themes, including attitudes, education, family, employment, heath, wellbeing, inclusion, markets, housing, taxes, inequality and power.
22.
Sakai, Tsubasa; Mersch, Dirk; Reisner, Erwin
Photocatalytic hydrogen evolution with a hydrogenase in a mediator-free system under high levels of oxygen Journal Article
In: Angewandte Chemie International Edition, vol. 52, no. 47, pp. 12313–12316, 2013.
@article{sakai2013photocatalytic,
title = {Photocatalytic hydrogen evolution with a hydrogenase in a mediator-free system under high levels of oxygen},
author = {Tsubasa Sakai and Dirk Mersch and Erwin Reisner},
url = {https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201306214},
year = {2013},
date = {2013-01-01},
journal = {Angewandte Chemie International Edition},
volume = {52},
number = {47},
pages = {12313--12316},
publisher = {WILEY-VCH Verlag Weinheim},
abstract = {An oxygen‐tolerant hydrogenase can be employed with a dye in a photocatalytic scheme for the generation of H2. The homogeneous system does not require a redox mediator and visible‐light irradiation yields high amounts of H2 even in the presence of air.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
An oxygen‐tolerant hydrogenase can be employed with a dye in a photocatalytic scheme for the generation of H2. The homogeneous system does not require a redox mediator and visible‐light irradiation yields high amounts of H2 even in the presence of air.
21.
MJ Kappers S-L Sahonta, D Zhu; Oliver, Rachel A
Properties of trench defects in InGaN/GaN quantum well structures Journal Article
In: physica status solidi (a), vol. 210, no. 1, pp. 195–198, 2013.
@article{sahonta2013properties,
title = {Properties of trench defects in InGaN/GaN quantum well structures},
author = {S-L Sahonta, MJ Kappers, D Zhu, Tim J Puchtler, T Zhu, SE Bennett, Colin Humphreys and Rachel A Oliver},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/pssa.201200408},
year = {2013},
date = {2013-01-01},
journal = {physica status solidi (a)},
volume = {210},
number = {1},
pages = {195--198},
publisher = {WILEY-VCH Verlag Berlin},
abstract = {The structural and optical properties of trench defects, which are poorly understood yet commonly occurring defects observed on the surfaces of InGaN multiple quantum wells (MQW), are reported. These defects comprise near‐circular trenches which enclose areas of MQW which give rise to a red shift in peak photoluminescence emission and a change in cathodoluminescence intensity with respect to the surrounding material. Atomic force microscopy shows that the height of trench‐enclosed areas differs from that of the surrounding quantum well structure, and that trenches are unrelated to the commonly observed V‐defects in InGaN films, despite being occasionally intersected by them. Cross‐sectional electron microscopy analysis of trenches with raised centres suggests that the red shift in the observed cathodoluminescence peak emission may be due to the quantum wells being thicker in the trench‐enclosed regions than in the surrounding quantum well area. The mechanism of trench formation and its implication for the control of the emission properties of light‐emitting diodes is discussed.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The structural and optical properties of trench defects, which are poorly understood yet commonly occurring defects observed on the surfaces of InGaN multiple quantum wells (MQW), are reported. These defects comprise near‐circular trenches which enclose areas of MQW which give rise to a red shift in peak photoluminescence emission and a change in cathodoluminescence intensity with respect to the surrounding material. Atomic force microscopy shows that the height of trench‐enclosed areas differs from that of the surrounding quantum well structure, and that trenches are unrelated to the commonly observed V‐defects in InGaN films, despite being occasionally intersected by them. Cross‐sectional electron microscopy analysis of trenches with raised centres suggests that the red shift in the observed cathodoluminescence peak emission may be due to the quantum wells being thicker in the trench‐enclosed regions than in the surrounding quantum well area. The mechanism of trench formation and its implication for the control of the emission properties of light‐emitting diodes is discussed.
20.
Reid, Benjamin PL; Zhu, Tongtong; Puchtler, Timothy J; Fletcher, Luke J; Chan, Christopher CS; Oliver, Rachel A; Taylor, Robert A
Origins of spectral diffusion in the micro-photoluminescence of single InGaN quantum dots Journal Article
In: Japanese Journal of Applied Physics, vol. 52, no. 8S, pp. 08JE01, 2013.
@article{reid2013origins,
title = {Origins of spectral diffusion in the micro-photoluminescence of single InGaN quantum dots},
author = {Benjamin PL Reid and Tongtong Zhu and Timothy J Puchtler and Luke J Fletcher and Christopher CS Chan and Rachel A Oliver and Robert A Taylor},
url = {https://iopscience.iop.org/article/10.7567/JJAP.52.08JE01/meta},
year = {2013},
date = {2013-01-01},
journal = {Japanese Journal of Applied Physics},
volume = {52},
number = {8S},
pages = {08JE01},
publisher = {IOP Publishing},
abstract = {We report on optical characterization of self-assembled InGaN quantum dots (QDs) grown on three GaN pseudo-substrates with differing threading dislocation densities. QD density is estimated via microphotoluminscence on a masked sample patterned with circular apertures, and appears to increase with dislocation density. A non-linear excitation technique is used to observe the sharp spectral lines characteristic of QD emission. Temporal variations of the wavelength of emission from single QDs are observed and attributed to spectral diffusion. The magnitude of these temporal variations is seen to increase with dislocation density, suggesting locally fluctuating electric fields due to charges captured by dislocations are responsible for the spectral diffusion in this system.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
We report on optical characterization of self-assembled InGaN quantum dots (QDs) grown on three GaN pseudo-substrates with differing threading dislocation densities. QD density is estimated via microphotoluminscence on a masked sample patterned with circular apertures, and appears to increase with dislocation density. A non-linear excitation technique is used to observe the sharp spectral lines characteristic of QD emission. Temporal variations of the wavelength of emission from single QDs are observed and attributed to spectral diffusion. The magnitude of these temporal variations is seen to increase with dislocation density, suggesting locally fluctuating electric fields due to charges captured by dislocations are responsible for the spectral diffusion in this system.
19.
Roessler, Florian; Cebo, Tomasz; Heffernan, Shane; Bond, Peter J
A Simulation Approach to Molecular Transport in Bacterial Reaction Chambers Journal Article
In: Biophysical Journal, vol. 104, no. 2, pp. 633a, 2013.
@article{roessler2013simulation,
title = {A Simulation Approach to Molecular Transport in Bacterial Reaction Chambers},
author = {Florian Roessler and Tomasz Cebo and Shane Heffernan and Peter J Bond},
url = {https://www.cell.com/biophysj/comments/S0006-3495(12)04745-5},
year = {2013},
date = {2013-01-01},
journal = {Biophysical Journal},
volume = {104},
number = {2},
pages = {633a},
publisher = {Elsevier},
abstract = {Bacterial microcompartments (BMCs) are capsid-like assemblies that serve as simple protein-based metabolic organelles in bacterial cells. BMCs consist of a few thousand shell proteins that encapsulate specific enzymes, thus sequestering and/or enhancing certain metabolic pathways that often involve toxic intermediates. BMCs represent promising targets for rational modification in bionanotechnology. Crystallographic structures of some BMC proteins suggest that dynamic pores may be present within shell assemblies, providing the means for the controlled transport of substrates, products, and cofactors in the absence of a selectively permeable membrane. However, experimental evidence regarding BMC molecular transport remains inconclusive. In this study, all-atom, explicitly solvated molecular dynamics simulations have been used to generate microsecond-timescale sampling of molecular transport through several homohexameric shell assemblies from the archetypal BMC, the carboxysome. The carboxysome is specialized for carbon fixation in cyanobacterial cells, converting atmospheric carbon dioxide into organic compounds via the encapsulated enzyme ribulose-1,5-bisphosphate carboxylase oxygenase (RuBisCO). It has been hypothesized that the shell may be porous to bicarbonate which is sequestered within the carboxysome following conversion to carbon dioxide, whilst oxygen may be excluded as it is known to inhibit the fixation process by RuBisCO. Molecular simulations have been used to characterize the permeability properties of carboxysome oligomers to water, salt, oxygen, carbon dioxide, and bicarbonate. Probability maps and corresponding potentials of mean force for selective transport of metabolic intermediates have been derived, and related to the size, electrostatics, and hydrogen-bonding characteristics of carboxysome capsid subunits. Moreover, conformationally dynamic regions of the BMC subunits were observed to partially occlude the pores, suggesting the possibility of gated transport. Overall, our observations provide insight into the molecular mechanisms of microcompartment transport, with fundamental implications for biological protein assemblies.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Bacterial microcompartments (BMCs) are capsid-like assemblies that serve as simple protein-based metabolic organelles in bacterial cells. BMCs consist of a few thousand shell proteins that encapsulate specific enzymes, thus sequestering and/or enhancing certain metabolic pathways that often involve toxic intermediates. BMCs represent promising targets for rational modification in bionanotechnology. Crystallographic structures of some BMC proteins suggest that dynamic pores may be present within shell assemblies, providing the means for the controlled transport of substrates, products, and cofactors in the absence of a selectively permeable membrane. However, experimental evidence regarding BMC molecular transport remains inconclusive. In this study, all-atom, explicitly solvated molecular dynamics simulations have been used to generate microsecond-timescale sampling of molecular transport through several homohexameric shell assemblies from the archetypal BMC, the carboxysome. The carboxysome is specialized for carbon fixation in cyanobacterial cells, converting atmospheric carbon dioxide into organic compounds via the encapsulated enzyme ribulose-1,5-bisphosphate carboxylase oxygenase (RuBisCO). It has been hypothesized that the shell may be porous to bicarbonate which is sequestered within the carboxysome following conversion to carbon dioxide, whilst oxygen may be excluded as it is known to inhibit the fixation process by RuBisCO. Molecular simulations have been used to characterize the permeability properties of carboxysome oligomers to water, salt, oxygen, carbon dioxide, and bicarbonate. Probability maps and corresponding potentials of mean force for selective transport of metabolic intermediates have been derived, and related to the size, electrostatics, and hydrogen-bonding characteristics of carboxysome capsid subunits. Moreover, conformationally dynamic regions of the BMC subunits were observed to partially occlude the pores, suggesting the possibility of gated transport. Overall, our observations provide insight into the molecular mechanisms of microcompartment transport, with fundamental implications for biological protein assemblies.
18.
Fiona Christie, Athene M Donald; Scherman, Oren A
Inhibition of Human Insulin Aggregation through Supramolecular Host-Guest Interactions Proceedings Article
In: BIOPOLYMERS, pp. 289–289, WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA 2013.
@inproceedings{christie2013inhibition,
title = {Inhibition of Human Insulin Aggregation through Supramolecular Host-Guest Interactions},
author = {Fiona Christie, Athene M Donald and Oren A Scherman},
url = {http://www.5z.com/23APS/23APS_online.pdf#page=185},
year = {2013},
date = {2013-01-01},
booktitle = {BIOPOLYMERS},
volume = {100},
number = {3},
pages = {289--289},
organization = {WILEY-BLACKWELL 111 RIVER ST, HOBOKEN 07030-5774, NJ USA},
abstract = {The stability of protein-based pharmaceuticals, such as insulin, is important for their production, storage, delivery and administration. Insulin is a peptide hormone capable of forming amyloid-like structures and as such can be problematic during the manufacture and delivery processes. The formation of ordered, amyloid-like structures in proteins has been associated with several diseases such as Alzheimer’s, Parkinson’s and type II diabetes, and is
now thought to be a generic feature of protein aggregation. As such, there is considerable interest in controlling their formation and gain better understanding of the aggregation process. Cucurbit[n]uril (CB[n]) homologues are a series of macrocyclic host molecules of which the larger CB[7] and CB[8] molecules are capable of binding guests containing an aromatic moiety, such as phenylalanine [1] (Figure 1). Herein, we report the effects of their complexation in aqueous media with human insulin and its aggregation-prone fragments. We show that the N-terminal phenylalanine residue of human insulin binds to CB[8] in a 2:1 molar ratio, resulting in an inhibition of the previously reported aggregation process [2]. Removal of the insulin from the CB host results in aggregation behaviour not observed in the complexed form, suggesting CB as a potential inhibitor of this type of phenomena.
},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
The stability of protein-based pharmaceuticals, such as insulin, is important for their production, storage, delivery and administration. Insulin is a peptide hormone capable of forming amyloid-like structures and as such can be problematic during the manufacture and delivery processes. The formation of ordered, amyloid-like structures in proteins has been associated with several diseases such as Alzheimer’s, Parkinson’s and type II diabetes, and is
now thought to be a generic feature of protein aggregation. As such, there is considerable interest in controlling their formation and gain better understanding of the aggregation process. Cucurbit[n]uril (CB[n]) homologues are a series of macrocyclic host molecules of which the larger CB[7] and CB[8] molecules are capable of binding guests containing an aromatic moiety, such as phenylalanine [1] (Figure 1). Herein, we report the effects of their complexation in aqueous media with human insulin and its aggregation-prone fragments. We show that the N-terminal phenylalanine residue of human insulin binds to CB[8] in a 2:1 molar ratio, resulting in an inhibition of the previously reported aggregation process [2]. Removal of the insulin from the CB host results in aggregation behaviour not observed in the complexed form, suggesting CB as a potential inhibitor of this type of phenomena.
now thought to be a generic feature of protein aggregation. As such, there is considerable interest in controlling their formation and gain better understanding of the aggregation process. Cucurbit[n]uril (CB[n]) homologues are a series of macrocyclic host molecules of which the larger CB[7] and CB[8] molecules are capable of binding guests containing an aromatic moiety, such as phenylalanine [1] (Figure 1). Herein, we report the effects of their complexation in aqueous media with human insulin and its aggregation-prone fragments. We show that the N-terminal phenylalanine residue of human insulin binds to CB[8] in a 2:1 molar ratio, resulting in an inhibition of the previously reported aggregation process [2]. Removal of the insulin from the CB host results in aggregation behaviour not observed in the complexed form, suggesting CB as a potential inhibitor of this type of phenomena.
17.
Kidambi, Piran R; Bayer, Bernhard C; Blume, Raoul; Wang, Zhu-Jun; Baehtz, Carsten; Weatherup, Robert S; Willinger, Marc-Georg; Schloegl, Robert; Hofmann, Stephan
Observing graphene grow: catalyst--graphene interactions during scalable graphene growth on polycrystalline copper Journal Article
In: Nano letters, vol. 13, no. 10, pp. 4769–4778, 2013.
@article{kidambi2013observing,
title = {Observing graphene grow: catalyst--graphene interactions during scalable graphene growth on polycrystalline copper},
author = {Piran R Kidambi and Bernhard C Bayer and Raoul Blume and Zhu-Jun Wang and Carsten Baehtz and Robert S Weatherup and Marc-Georg Willinger and Robert Schloegl and Stephan Hofmann},
url = {https://pubs.acs.org/doi/abs/10.1021/nl4023572},
year = {2013},
date = {2013-01-01},
journal = {Nano letters},
volume = {13},
number = {10},
pages = {4769--4778},
publisher = {American Chemical Society},
abstract = {Complementary in situ X-ray photoelectron spectroscopy (XPS), X-ray diffractometry, and environmental scanning electron microscopy are used to fingerprint the entire graphene chemical vapor deposition process on technologically important polycrystalline Cu catalysts to address the current lack of understanding of the underlying fundamental growth mechanisms and catalyst interactions. Graphene forms directly on metallic Cu during the high-temperature hydrocarbon exposure, whereby an upshift in the binding energies of the corresponding C1s XPS core level signatures is indicative of coupling between the Cu catalyst and the growing graphene. Minor carbon uptake into Cu can under certain conditions manifest itself as carbon precipitation upon cooling. Postgrowth, ambient air exposure even at room temperature decouples the graphene from Cu by (reversible) oxygen intercalation. The importance of these dynamic interactions is discussed for graphene growth, processing, and device integration.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Complementary in situ X-ray photoelectron spectroscopy (XPS), X-ray diffractometry, and environmental scanning electron microscopy are used to fingerprint the entire graphene chemical vapor deposition process on technologically important polycrystalline Cu catalysts to address the current lack of understanding of the underlying fundamental growth mechanisms and catalyst interactions. Graphene forms directly on metallic Cu during the high-temperature hydrocarbon exposure, whereby an upshift in the binding energies of the corresponding C1s XPS core level signatures is indicative of coupling between the Cu catalyst and the growing graphene. Minor carbon uptake into Cu can under certain conditions manifest itself as carbon precipitation upon cooling. Postgrowth, ambient air exposure even at room temperature decouples the graphene from Cu by (reversible) oxygen intercalation. The importance of these dynamic interactions is discussed for graphene growth, processing, and device integration.
16.
Mertens, Jan; Eiden, Anna L; Sigle, Daniel O; Huang, Fumin; Lombardo, Antonio; Sun, Zhipei; Sundaram, Ravi S; Colli, Alan; Tserkezis, Christos; Aizpurua, Javier; others,
Controlling subnanometer gaps in plasmonic dimers using graphene Journal Article
In: Nano letters, vol. 13, no. 11, pp. 5033–5038, 2013.
@article{mertens2013controlling,
title = {Controlling subnanometer gaps in plasmonic dimers using graphene},
author = {Jan Mertens and Anna L Eiden and Daniel O Sigle and Fumin Huang and Antonio Lombardo and Zhipei Sun and Ravi S Sundaram and Alan Colli and Christos Tserkezis and Javier Aizpurua and others},
url = {https://pubs.acs.org/doi/abs/10.1021/nl4018463},
year = {2013},
date = {2013-01-01},
journal = {Nano letters},
volume = {13},
number = {11},
pages = {5033--5038},
publisher = {American Chemical Society},
abstract = {Graphene is used as the thinnest possible spacer between gold nanoparticles and a gold substrate. This creates a robust, repeatable, and stable subnanometer gap for massive plasmonic field enhancements. White light spectroscopy of single 80 nm gold nanoparticles reveals plasmonic coupling between the particle and its image within the gold substrate. While for a single graphene layer, spectral doublets from coupled dimer modes are observed shifted into the near-infrared, these disappear for increasing numbers of layers. These doublets arise from charger-transfer-sensitive gap plasmons, allowing optical measurement to access out-of-plane conductivity in such layered systems. Gating the graphene can thus directly produce plasmon tuning.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Graphene is used as the thinnest possible spacer between gold nanoparticles and a gold substrate. This creates a robust, repeatable, and stable subnanometer gap for massive plasmonic field enhancements. White light spectroscopy of single 80 nm gold nanoparticles reveals plasmonic coupling between the particle and its image within the gold substrate. While for a single graphene layer, spectral doublets from coupled dimer modes are observed shifted into the near-infrared, these disappear for increasing numbers of layers. These doublets arise from charger-transfer-sensitive gap plasmons, allowing optical measurement to access out-of-plane conductivity in such layered systems. Gating the graphene can thus directly produce plasmon tuning.
15.
Li, Wenhong; Bell, Nicholas AW; Hernández-Ainsa, Silvia; Thacker, Vivek V; Thackray, Alana M; Bujdoso, Raymond; Keyser, Ulrich F
Single protein molecule detection by glass nanopores Journal Article
In: ACS nano, vol. 7, no. 5, pp. 4129–4134, 2013.
@article{li2013single,
title = {Single protein molecule detection by glass nanopores},
author = {Wenhong Li and Nicholas AW Bell and Silvia Hernández-Ainsa and Vivek V Thacker and Alana M Thackray and Raymond Bujdoso and Ulrich F Keyser},
url = {https://pubs.acs.org/doi/abs/10.1021/nn4004567},
year = {2013},
date = {2013-01-01},
journal = {ACS nano},
volume = {7},
number = {5},
pages = {4129--4134},
publisher = {American Chemical Society},
abstract = {Nanopores can be used to detect and analyze single molecules in solution. We have used glass nanopores made by laser-assisted capillary-pulling, as a high-throughput and low cost method, to detect a range of label-free proteins: lysozyme, avidin, IgG, β-lactoglobulin, ovalbumin, bovine serum albumin (BSA), and β-galactosidase in solution. Furthermore, we show for the first time solid state nanopore measurements of mammalian prion protein, which in its abnormal form is associated with transmissible spongiform encephalopathies. Our approach provides a basis for protein characterization and the study of protein conformational diseases by nanopore detection.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Nanopores can be used to detect and analyze single molecules in solution. We have used glass nanopores made by laser-assisted capillary-pulling, as a high-throughput and low cost method, to detect a range of label-free proteins: lysozyme, avidin, IgG, β-lactoglobulin, ovalbumin, bovine serum albumin (BSA), and β-galactosidase in solution. Furthermore, we show for the first time solid state nanopore measurements of mammalian prion protein, which in its abnormal form is associated with transmissible spongiform encephalopathies. Our approach provides a basis for protein characterization and the study of protein conformational diseases by nanopore detection.
2012
14.
Bell, Nicholas AW; Engst, Christian R; Ablay, Marc; Divitini, Giorgio; Ducati, Caterina; Liedl, Tim; Keyser, Ulrich F
DNA origami nanopores Journal Article
In: Nano letters, vol. 12, no. 1, pp. 512–517, 2012.
@article{bell2012dna,
title = {DNA origami nanopores},
author = {Nicholas AW Bell and Christian R Engst and Marc Ablay and Giorgio Divitini and Caterina Ducati and Tim Liedl and Ulrich F Keyser},
url = {https://pubs.acs.org/doi/abs/10.1021/nl204098n},
year = {2012},
date = {2012-01-01},
journal = {Nano letters},
volume = {12},
number = {1},
pages = {512--517},
publisher = {American Chemical Society},
abstract = {We demonstrate the assembly of functional hybrid nanopores for single molecule sensing by inserting DNA origami structures into solid-state nanopores. In our experiments, single artificial nanopores based on DNA origami are repeatedly inserted in and ejected from solid-state nanopores with diameters around 15 nm. We show that these hybrid nanopores can be employed for the detection of λ-DNA molecules. Our approach paves the way for future development of adaptable single-molecule nanopore sensors based on the combination of solid-state nanopores and DNA self-assembly.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
We demonstrate the assembly of functional hybrid nanopores for single molecule sensing by inserting DNA origami structures into solid-state nanopores. In our experiments, single artificial nanopores based on DNA origami are repeatedly inserted in and ejected from solid-state nanopores with diameters around 15 nm. We show that these hybrid nanopores can be employed for the detection of λ-DNA molecules. Our approach paves the way for future development of adaptable single-molecule nanopore sensors based on the combination of solid-state nanopores and DNA self-assembly.
13.
Thacker, Vivek V; Ghosal, Sandip; Hernández-Ainsa, Silvia; Bell, Nicholas AW; Keyser, Ulrich F
Studying DNA translocation in nanocapillaries using single molecule fluorescence Journal Article
In: Applied physics letters, vol. 101, no. 22, pp. 223704, 2012.
@article{thacker2012studying,
title = {Studying DNA translocation in nanocapillaries using single molecule fluorescence},
author = {Vivek V Thacker and Sandip Ghosal and Silvia Hernández-Ainsa and Nicholas AW Bell and Ulrich F Keyser},
url = {https://aip.scitation.org/doi/abs/10.1063/1.4768929},
year = {2012},
date = {2012-01-01},
journal = {Applied physics letters},
volume = {101},
number = {22},
pages = {223704},
publisher = {American Institute of Physics},
abstract = {We demonstrate simultaneous measurements of DNA translocation into glass nanopores using ionic current detection and fluorescent imaging. We verify the correspondence between the passage of a single DNA molecule through the nanopore and the accompanying characteristic ionic current blockage. By tracking the motion of individual DNA molecules in the nanocapillary perpendicular to the optical axis and using a model, we can extract an effective mobility constant for DNA in our geometry under high electric fields.
},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
We demonstrate simultaneous measurements of DNA translocation into glass nanopores using ionic current detection and fluorescent imaging. We verify the correspondence between the passage of a single DNA molecule through the nanopore and the accompanying characteristic ionic current blockage. By tracking the motion of individual DNA molecules in the nanocapillary perpendicular to the optical axis and using a model, we can extract an effective mobility constant for DNA in our geometry under high electric fields.